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AUTO IMMUNE TESTING

Predictive Autoimmunity Testing

The mucosal immune system is constantly exposed to challenges from the antigenic substances found in food and released from the body's own microbial flora. The body's normal tolerance to friendly antigenic substances can be disrupted by a number of factors, such as disease, injury, shock, trauma, surgery, drugs, blood transfusion, environmental triggers, etc.

When this disruption happens, the ingestion of foods containing antigenic substances that have compositions similar to those of the body's autoantigens can result in the production of antibodies that react not only against the food antigens but also the body's own tissues.

 

This response is known as food autoimmune reactivity. Between 7% and 10% of the world's population suffers from some form of autoimmune disease

As a top immuno-neurologist with an interest in reducing the number of environmental toxins we expose our immune systems to, what kind of support have you found in the medical community for your work?

[The] "answer depends upon the definition of medical community. If you are asking about complementary and alternative medicine, absolutely, yes. If you are talking about functional medicine, they absolutely recognize these types of abnormalities. There are thousands and thousands of articles in scientific journals beginning 40 years ago and con-tinuing on through today. Unfortunately, the medical doctors who are practicing medicine do not have time to read these scientific journal articles. Therefore, they are not educated in the field and do not recognize that environmental toxins and infectious agents and dietary proteins and peptides can induce autoimmunities."

Aristo Vojdani, PhD: Environmental Factors and Autoimmune Disease

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Table 1. Types of molecular mimicry.

Type 1

Definition: Complete identity at the protein level between a microorganism and its host, of a protein not encoded by the microorganism.

 

Experimental scenario: CMV acquire the CD13 and incorporate it on the viral envelope. This CD13 has shown to induce an immune reaction against CD13-positive cells such as all mononuclear cells, fibroblast and smooth muscle which ultimately are associated with graft-versus-host disease.[47,55]

Type 2

Definition: Homology at the protein level between a microorganism and its host, of a protein encoded by the microorganism.

Experimental scenario: Helicobacter pylori codifies for α-carbonic anhydrase which share significant homology with the human carbonic anhydrase II. This mechanism gives an advantage to this microbe since can proliferate in the gastric environment.[47,53]

Type 3

Definition: Common or similar amino acid sequences or epitopes between the microorganisms or environmental agent and its host.

Experimental scenario: Polysaccharides on the C. jejuni membrane share homology with carbohydrates structures that are found in the myelin sheath of peripheral axons.[6,13,47]

 

Type 4

Definition:  Structural similarities between the microbe or environmental agent and its host.

Experimental scenario: Structurally homology between the DRB1*15:01-restricted MBP and the DRB5*01:01-restricted EBV peptide were associated with cross-reactivity.

References

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